Mechanisms And Modulation Of Macrophage Activation Syndrome CriteriaImmune Restoration Jeremy E. Kaslow, M. D. It is becoming increasingly evident that many if not most chronic conditions are based in large part on an infection and immune response. This includes more than just hepatitis, HIV, EBV, etc., or with the manifestations of CFIDS, Candidiasis, certain forms of cervical dysplasia, Gulf War Syndrome GWS, atherosclerosis, and cancer. All of these examples there is a clear component of infection and immune response as key contributors to the disease condition. Arthritis, fibromyalgia, coronary artery disease, ulcers, psoriasis, inflammatory bowel disease, multiple sclerosis, are just a  few of the conditions in which infection and immune response appear to be the driving force in the disease. While anti microbials seem the logical approach, there is a growing realization that immunology may be the approach that provides long term answers. Restoring balance and function to your immune system, in the face of a chronic infectious viral, bacterial, fungal, parasitic, etc challenge is a fundamental challenge necessary for recovery. To understand the therapeutic approach and goal of optimal immunity, you must know a little bit about cytokines, which ultimately control our immune responses. Using nutrients and many other factors to induce or suppress specific cytokine responses is one approach that will be explored in this web page. Cytokines are chemical messengers that control immune responses. They are secreted primarily by white blood cells, T lymphocytes, and epithelial cells. There are two general groupings of cytokines based on the effect they have on lymphocytes Th. Th. 2.   The balance between Th. A10.1038%2Fs41598-017-00840-2/MediaObjects/41598_2017_840_Fig6_HTML.jpg' alt='Mechanisms And Modulation Of Macrophage Activation Syndrome Pdf' title='Mechanisms And Modulation Of Macrophage Activation Syndrome Pdf' />Granulocytemacrophage colonystimulating factor GMCSF, also known as colonystimulating factor 2 CSF2, is a monomeric glycoprotein secreted by macrophages, T. The blood coagulation page provides details of the normal processes of hemostasis and mechanisms for therapeutic intervention in abnormal bleeding. The notion that heart attacks develop from coronaryartery stenosis is an oversimplification of a process involving lipid metabolism, inflammation, macrophage. Th. 2 determines the type of immune response and the resultant health or disease that results. Th. 1 T cell Helper type 1 promote cell mediated immunity CMI while Th. T cell Helper type 2 induce humoral immunity. Viral infections are largely controlled by cells fighting the virus, while humoral immunity involves antibody formation. Robert Darga MD describes, Two different methods exist by which the body fights infections humoral immunity Th. Th. 1 directs Killer T cells CD8 to attack microorganisms or abnormal cells at the sites of infection inside the cells. In chronic viral disease, the worst of which is the HIV progression to AIDS, there is a shift from Th. Th. 2 humoral immunity. Since antibodies are not as effective in defeating viruses as are the cells themselves, viral diseases progress when there is a shift from Th. Th. 2. The term cytokine is derived from the term for cells cyto as in cytology and the term for action or movement kine from the word kinetic. They include chemicals that induce cells into a particular action. Some of the cytokines include interleukins and the 3 classes of interferons called alpha, beta and gamma and various subsets. The term interferon is derived from its role to interfere with infection. Th. 1 or Th. 2 There are multiple factors that affect either Th. Th. 2 cytokines.   Th. Interleukin 2 IL 2, Interleukin 1. IL 1. 2, gamma interferon IFN gamma, and Ig. A an immunoglobulin that supports mucosal immunity. The Th. 2 immune response is enhanced by interleukins 4, 5, 6 and 1. In many cases, an infection is fought with both arms of the immune system at other times only one is needed to control the infection. A failure of the Th. Th. 2 arm is implicated in a wide variety of chronic illnesses. These include AIDS, CFIDS, Candidiasis, Multiple allergies, Multiple Chemical Sensitivities MCS, viral hepatitis, Gulf War Syndrome GWS, cancer, etc. If these two arms of the immune system could be balanced by stimulating Th. Th. 2, then many of the symptoms associated with these chronic illnesses would diminish or disappear and we would have found the answer to immune restoration and balance or the equivalent of a cure. With AIDS, it has been reported that as HIV infection progresses from the asymptomatic stage to advanced disease, the immune response appears to shift from the more effective Th. Th. 2 state. The Need for Balance. It is important to realize that a normal functioning immune system needs both arms Th. Th. 2 to provide flexibility to respond to different kinds of pathogens viruses, fungi, mycoplasmas and bacteria etc both inside and outside of the cells. If the Th. 2 arm is chronically over active as is found in many chronic disease states such as viral infections, candidiasis, and cancer, while the Th. In end stage illnesses, both arms of immune system fail. IL 1. 2 Ig. A for Mucosal Immunity. The skin and mucus membranes are the bodys primary barrier to keep out unwanted pathogens. An open cut andor a leaky gut is like a fortress with an open door. Viruses, fungus bacteria, parasites, etc have easy access to get inside. Il 1. Killer T cells in the mucus membranes to stop viral invasions before they get enter the body. Restoring normal Ig. A in the mucus membranes is also critical to help reduce infectious agents, foods and chemical entry into the body. Clearly restoring mucosal immunity is a critical first step to take in immune restoration. The epithelium mucus membranes of the intestines are a fine filter to let nutrients in and keep out unusable food particles. When pathogens like certain bacteria, candida albicans, parasites, etc., replicate in or on the mucus membranes, they inflame the epithelium and create a leaky gut that allows byproducts of faulty digestion to enter the blood. This triggers an antibody response Th. Th. 1.   This is the basis of a leaky gut increased intestinal permeability discussed in more detail in another webpage. Multiple studies show that high levels of Ig. A and CD8 Killer T cells in the mucus membranes of the colon orand vagina increase the resistance to viral and bacterial infections. To increase the CD8 Killer T cells in the mucus membranes and throughout the body, Th 1 promoters need to be induced with resultant Ig. A, IL 1. 2, and interferon gamma IFN gamma production the key cytokines for restoring mucosal and systemic cellular immunity. FACTORS THAT INCREASE Th. Readiris Pro 12 Download Cracked. CYTOKINESThe three most common factors that drive Th. Faulty digestion leading to absorption of partially digested and unusable proteins and other food particles increases Ig. G and Ig. E antibody responses that are directed against these foreign food particles. This is the condition called leaky gut due to increased intestinal permeability. Instead of the intestines serving as a barrier to the outside world, it allows an excessive amount of particles to be presented to the body through a non physiologic entryway. Just as if you entered a home with a security system through a window, the alarm is triggered and you are alerted to a foreign invader. The result is a recruitment of police and other protective mechanisms, in the case of the food this represents the immune system. Proper digestion, a balance of friendly supportive bacteria, and a healthy gastrointestinal lining create a strong barrier to improper entry. Likewise, use of digestive enzymes, eating slowly mixing lots of saliva with food, avoiding over eating or processed foods that are difficult to digest, anti microbial therapy, etc.